The ONE POT SYNTHESIS OF HIGHLY FUNCTIONALIZED TETRAHYDROPYRIDINES UTILIZING NANO-TICL2/ CELLULOSE AS BIODEGRADABLE As Well As ECO-FRIENDLY CATALYST

Abstract

Nano-TiCl2/cellulose was used as an efficient and biodegradable Lewis acid catalyst for the synthesis of highly functionalized tetrahydropyridines by one-pot multi component reactions of amines and aldehydes with β-ketoester. The catalyst was prepared via reaction of nano-cellulose and TiCl4 and characterized by Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), powder X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), X-ray fluorescence techniques (XRF) and transmission electron microscopy (TEM). Simple methodology, eco-friendly catalyst, clean procedure, easy work-up and high yields are some of the important advantages of this protocol.